Key result
In awake dogs, lactic acid injection into respiratory muscle arteries increased mean arterial blood pressure by 21% and reduced cardiac output and hindlimb blood flow at rest and during exercise.
Population
Awake dogs
Design
Preclinical
Authors
Loading...
No immediate clinical implications; extends metaboreflex findings to respiratory muscles in awake animals but leaves human relevance open.
Activation of the respiratory muscle metaboreflex via lactic acid injection in dogs elicits cardiovascular responses similar to limb muscles, potentially contributing to increased sympathetic tone and blood flow redistribution during exercise.
Rodman et al. (2003) studied Awake dogs (animal model). Lactic acid injection into phrenic and deep circumflex iliac arteries vs. Baseline/rest and adrenergic receptor blockade was evaluated on Cardiovascular responses (mean arterial blood pressure, cardiac output, blood flow to hindlimbs). In awake dogs, lactic acid injection into respiratory muscle arteries increased mean arterial blood pressure by 21% and reduced cardiac output and hindlimb blood flow at rest and during exercise.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: