What does this research mean for the field?

Cardiac vagal efferent fibers conduct at 4 to 12 m/sec, are predominantly spontaneously active, and have their spontaneous and reflexive discharges inhibited during inspiration and by non-specific nerve stimulation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the activity of cardiac vagal efferent fibers and their response to sinus nerve stimulation.

January 1, 1964The Japanese Journal of Physiology

Activity of Single Vagal Fibers Efferent to the Heart

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Population

Dogs anesthetized with morphine, chloralose and urethane

Design

Preclinical

Authors

JIJuro IriuchijimaCMIC Group (Japan)MKMamoru KumadaThe University of Tokyo

Discussion

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Implication

Characterizes cardiac vagal conduction and inhibition in canines; leaves open translation to human cardiorespiratory reflexes.

Key Points

This research investigates the activity of cardiac vagal efferent fibers and their response to sinus nerve stimulation.
Fine strands of the cervical vagus in anesthetized dogs were analyzed for cardiac vagal fiber activity.
Conduction rates of the fibers were measured, and their responsiveness to sinus nerve stimulation was assessed.
Spontaneous and reflexive discharges during respiration were observed.
Cardiac vagal fibers had conduction rates between 4 to 12 m/sec, averaging 8 m/sec.
Most fibers were spontaneously active and showed inhibited activity during inhalation.
Reflex discharge to sinus nerve stimulation was inhibited by simultaneous stimulation of multiple nerves.

Structured PICO

Population

Dogs anesthetized with morphine, chloralose and urethane

Intervention

Sinus nerve stimulation and simultaneous stimulation of vagus, sciatic, brachial or saphenous nerve

Outcome

Activity, conduction rates, and discharge patterns of cardiac vagal efferent fiberssurrogate

This preclinical study characterizes the conduction rates and inhibitory reflex pathways of cardiac vagal efferent fibers in a canine model.

Cite This Study

Iriuchijima et al. (1964) studied this question.

synapsesocial.com/papers/6a19b09f3f3ec013f0deed6f https://doi.org/10.2170/jjphysiol.14.479

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Activity of Single Vagal Fibers Efferent to the Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Activity of Single Vagal Fibers Efferent to the Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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