Why the study?
How do plasma growth hormone levels respond to stimulation in normal children compared to those with growth disorders?
Population
Normal children, children with pituitary or hypothalamic disorders, children with idiopathic growth hormone…
Comparison
Stimulation with insulin hypoglycemia, arginine… vs Normal children and fasting state
Design
Cross-sectional
Authors
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May support GH testing to distinguish idiopathic GHD from constitutional delay; leaves open prospective validation.
How do plasma growth hormone levels respond to stimulation in normal children compared to those with growth disorders?
Constitutional delay in growth is not associated with abnormalities in growth hormone responses to stimulation, unlike idiopathic growth hormone deficiency.
Frohman et al. (1967) studied this question.
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