October 27, 1983New England Journal of Medicine

Growth Hormone Treatment for Short Stature

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Why the study?

Does pituitary growth hormone increase growth rate in short normal children?

Population

29 children: 15 short but otherwise normal children and 14 children with documented growth hormone deficiency.

Design

Cohort

Follow-up

six months

Authors

GVGuy Van VlietCentre Hospitalier Universitaire Sainte-Justine DSDennis M. StyneUniversity of California, Davis SKSelna L. KaplanOregon National Primate Research Center

Discussion

Member takes

Implication

GH may accelerate short-term growth in some short normal children; hypothesis-generating and should not yet change practice.

Structured PICO

Does pituitary growth hormone increase growth rate in short normal children?

Population

29 children: 15 short but otherwise normal children (4.3 to 15.5 years old, height >3 S.D. below mean, growth rate ≤5.0 cm per year, normal GH response ≥10 ng/mL) and 14 children with documented growth hormone deficiency.

Intervention

Pituitary growth hormone 0.1 U per kilogram intramuscularly three times weekly for six months.

Outcome

Growth ratesurrogate

A dose of growth hormone comparable to that used for hypopituitarism increases growth rate in some short normal children.

Cite This Study

Vliet et al. (1983) studied this question.

synapsesocial.com/papers/6a72573b6ceb2bbd16e05754 https://doi.org/10.1056/nejm198310273091703

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Bookmark

Growth Hormone Treatment for Short Stature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Growth Hormone Treatment for Short Stature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider