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January 1, 2013International Archives of MedicineOpen Access

A new era of stroke prevention in atrial fibrillation: comparing a new generation of oral anticoagulants with warfarin

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Why the study?

Do novel oral anticoagulants (NOACs) prevent stroke and systemic embolism as effectively and safely as warfarin in patients with atrial fibrillation?

Population

Patients with atrial fibrillation at moderate to high risk of stroke, including those with risk factors such…

Comparison

Novel oral anticoagulants as a class… vs Dose-adjusted warfarin requiring regular…

Design

Review

Authors

BSBruce S. Stambler

Discussion

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Overview

NOACs may be considered over warfarin in AF; confirms RCT summaries but leaves real-world applicability open.

Structured PICO

Do novel oral anticoagulants (NOACs) prevent stroke and systemic embolism as effectively and safely as warfarin in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation (AF) at moderate to high risk of stroke, including those with risk factors such as prior stroke or transient ischemic attack (TIA), congestive heart failure, left ventricular ejection fraction ≤35%, hypertension, age ≥75 years, or diabetes.
I
Intervention
Novel oral anticoagulants (NOACs) as a class, specifically including the direct thrombin inhibitor dabigatran (110 mg or 150 mg twice daily) and the factor Xa inhibitors rivaroxaban (20 mg once daily), apixaban (5 mg twice daily), and edoxaban.
C
Comparator
Dose-adjusted warfarin (vitamin K antagonist) requiring regular international normalized ratio (INR) monitoring.
O
Outcome
Prevention of stroke or systemic embolism.hard clinical

NOACs provide an effective, predictable, and convenient alternative to warfarin for stroke prevention in atrial fibrillation without the need for routine INR monitoring.

Cite This Study

Bruce S. Stambler (2013) studied this question.

synapsesocial.com/papers/6a19b3c6443d3ecd7cdee916https://doi.org/10.1186/1755-7682-6-46
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