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February 14, 2012Therapeutic Advances in Chronic DiseaseOpen Access

Novel anticoagulants in atrial fibrillation stroke prevention

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Why the study?

Do novel oral anticoagulants prevent stroke compared to warfarin in patients with atrial fibrillation?

Population

Patients with atrial fibrillation (AF)

Comparison

Novel oral anticoagulants vs Warfarin

Design

Review

Authors

NNNicholas B. NorgardJDJames J. DiNicolantonioTTTaylor J Topping

Discussion

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Overview

May support NOAC preference over warfarin in AF; leaves open optimal agent selection and real-world bleeding risks.

Structured PICO

Do novel oral anticoagulants prevent stroke compared to warfarin in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation (AF)
I
Intervention
Novel oral anticoagulants (dabigatran, rivaroxaban, apixaban)
C
Comparator
Warfarin
O
Outcome
Prevention of strokehard clinical

Novel oral anticoagulants offer an effective and potentially safer alternative to warfarin for stroke prevention in patients with atrial fibrillation.

Cite This Study

Norgard et al. (2012) studied this question.

synapsesocial.com/papers/6a1bc2eeb33628da419cd0fahttps://doi.org/10.1177/2040622312438934
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stroke Prevention in Atrial Fibrillation2012 · 9 citations
  2. 2Novel Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation2013 · 3 citations
  3. 3Novel Oral Anticoagulants for Stroke Prevention in Patients with Atrial Fibrillation: Dawn of a New Era2013 · 6 citations
  4. 4New anticoagulant treatments to protect against stroke in atrial fibrillation2012 · 41 citations
  5. 5Antithrombotic Therapy in Atrial Fibrillation - Evaluation and Positioning of New Oral Anticoagulant Agents -2011 · 55 citations