September 29, 2010Journal of Magnetic Resonance Imaging
Late gadolinium enhancement of acute myocardial infarction in mice at 7T: Cine‐FLASH versus inversion recovery
Why the study?
Does cine-FLASH LGE MRI provide comparable quantification of MI size compared to IR LGE MRI in mice at 7T?
Population
14 mice with acute myocardial infarction (5 used to optimize parameters, 9 imaged 2-3 days after MI)
Comparison
Cine fast low shot angle late gadolinium… vs Inversion recovery fast gradient echo late…
Design
Preclinical
Follow-up
2-3 days after MI
Authors
Discussion
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Member takes
Implication
Supports faster murine MI quantification at 7T; leaves open translation to clinical imaging.
Structured PICO
Does cine-FLASH LGE MRI provide comparable quantification of MI size compared to IR LGE MRI in mice at 7T?
P
Population
14 mice with acute myocardial infarction (5 used to optimize parameters, 9 imaged 2-3 days after MI)
I
Intervention
Cine fast low shot angle (cine-FLASH) late gadolinium enhancement MRI at 7T
C
Comparator
Inversion recovery (IR) fast gradient echo late gadolinium enhancement MRI at 7T
O
Outcome
Quantification of myocardial infarction sizesurrogate
Cine-FLASH LGE MRI at 7T is a faster, robust alternative to IR LGE MRI for assessing infarct size in mice, providing similar accuracy to histology.
Cite This Study
Protti et al. (2010) studied this question.