January 1, 2011Journal of Cardiovascular Magnetic ResonanceOpen Access

Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T

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Population

Rodent models of myocardial infarction: acute reperfused model of MI in rats and mice 2 days following…

Comparison

Multi-slice inversion recovery gradient echo… vs Triphenyltetrazolium chloride staining

Design

Preclinical

Authors

APAnthony N. PriceKing's College London KCKing Kenneth CheungNorth District Hospital SLShiang Y. LimThe University of Melbourne

Discussion

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Implication

Validates LGE for rodent infarct sizing at 9.4T; extends preclinical methods but leaves clinical translation open.

Structured PICO

Population

Rodent models of myocardial infarction: acute (2 hour) reperfused model of MI in rats and mice 2 days following non-reperfused MI

Intervention

Multi-slice inversion recovery (IR) gradient echo sequence with an additional Look-Locker sequence for LGE CMR at 9.4T

Comparator

Triphenyltetrazolium chloride (TTC) staining (in rats)

Outcome

Assessment of myocardial infarct size and image qualitysurrogate

A multi-slice inversion recovery LGE CMR protocol at 9.4T provides a reliable and fast method for assessing myocardial infarct size in rodent models.

Cite This Study

Price et al. (2011) studied this question.

synapsesocial.com/papers/6a7d5637f1daba58ecd5b606 https://doi.org/10.1186/1532-429x-13-44

Topics

Cardiac MRI

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Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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