Why the study?
Does insulin stimulate endothelin receptor expression and cell proliferation in vascular smooth muscle cells?
Population
Cultured vascular smooth muscle cells, aortic smooth muscle cells, brain capillary pericytes, and kidney…
Comparison
Insulin treatment and endothelin-1 vs Control
Design
Preclinical
Authors
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May link hyperinsulinemia to VSMC proliferation via ET receptors in animals; leaves open human translation and clinical relevance.
Does insulin stimulate endothelin receptor expression and cell proliferation in vascular smooth muscle cells?
Insulin stimulates endothelin receptor expression and potentiates endothelin-1-induced cell proliferation in vascular smooth muscle cells, suggesting a mechanism for accelerated vascular disease in hyperinsulinemia.
Frank et al. (1993) studied this question.
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