Hyperglycemia in STZ-induced diabetic rats elevates plasma ET-1, leading to desensitization of ET(A) and ET(B) receptors in the mesenteric arterial bed, which can be reversed by insulin therapy.
No takes yet. Share an insight, caveat, or question.
Animal data suggest insulin may normalize diabetic ET receptor function; hypothesis-generating and requires human validation.
Makino et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: