Key result
Endothelin-1 induced altered vascular endothelial responses in STZ-diabetic rats compared to normal rats, particularly in the ophthalmic circulation where ETA receptor antagonism reduced ET-1-induced vasodilation only in diabetic animals.
Population
36 Sprague-Dawley rats, age 13-17 weeks. Diabetic rats had blood glucose >20 mmol/l after streptozotocin…
Comparison
Endothelin-1 infusion with or without… vs Normal Sprague-Dawley rats receiving the same…
Design
Preclinical
Authors
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These rat findings warrant no clinical change in diabetic care; leaves open ETA targeting for human ophthalmic vasculopathy.
STZ-diabetic rats exhibit altered vascular endothelial responses to ET-1, particularly in the ophthalmic circulation, suggesting differential receptor involvement compared to normal rats.
Granstam et al. (2011) studied Diabetes mellitus (n=36). Endothelin-1 (ET-1) vs. Baseline / Non-diabetic controls was evaluated on Change in regional blood flow and vascular resistance. Endothelin-1 induced altered vascular endothelial responses in STZ-diabetic rats compared to normal rats, particularly in the ophthalmic circulation where ETA receptor antagonism reduced ET-1-induced vasodilation only in diabetic animals.
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