Key result
Preoperative optimisation of oxygen delivery significantly reduced hospital mortality compared to routine perioperative care (3% vs 17%, P=0.007).
Why the study?
Does preoperative optimisation of oxygen delivery using adrenaline or dopexamine reduce hospital mortality and morbidity in patients undergoing major elective surgery at risk of complications?
Population
138 patients undergoing major elective surgery who were at risk of developing postoperative complications…
Comparison
Preoperative optimisation of oxygen delivery… vs Routine perioperative care.
Design
RCT, Randomised into three groups, Double blinding between inotrope groups
Follow-up
Until hospital discharge
Authors
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Supports preoperative oxygen optimization in high-risk elective surgery; confirms mortality benefit over routine care.
RCT (n=138)
Double-blind
Randomized into three groups
No
Does preoperative optimisation of oxygen delivery using adrenaline or dopexamine reduce hospital mortality and morbidity in patients undergoing major elective surgery at risk of complications?
Absolute Event Rate: 3% vs 17%
p-value: p=0.007
Preoperative optimization of oxygen delivery, particularly with dopexamine, significantly reduces hospital mortality and complications in high-risk patients undergoing major elective surgery.
Wilson et al. (1999) conducted an RCT in Major elective surgery at risk of postoperative complications (n=138). Preoperative optimisation of oxygen delivery (invasive haemodynamic monitoring, fluid, and adrenaline or dopexamine) vs. Routine perioperative care was evaluated on Hospital mortality (p=0.007). Preoperative optimisation of oxygen delivery significantly reduced hospital mortality compared to routine perioperative care (3% vs 17%, P=0.007).
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