Key result
A latest CD4 count <100 cells/μl in HIV patients was not associated with higher MI risk (RR 0.96; 95% CI 0.62-1.50) but was associated with higher stroke risk (RR 2.26; 95% CI 1.29-3.94).
Why the study?
Does immune depression increase the risk of cardiovascular events in HIV-positive individuals?
Population
33,301 HIV-positive individuals
Comparison
Immune depression vs Higher CD4 cell counts / absence of immune…
Design
Cohort
Authors
Loading...
Does not support CD4-guided MI risk stratification in HIV; leaves open stroke association for prospective confirmation.
Cohort (n=33,301)
Does immune depression increase the risk of cardiovascular events in HIV-positive individuals?
Effect estimate: RR 0.96 (95% CI 0.62-1.50)
In HIV-positive individuals, severe immune depression (CD4 <100 cells/μl) is associated with an increased risk of stroke but not myocardial infarction or coronary heart disease.
Sabin et al. (2013) conducted a cohort in HIV infection (n=33,301). Latest/nadir CD4 cell count <100 cells/μl vs. Higher CD4 cell counts was evaluated on Myocardial infarction (MI) (RR 0.96, 95% CI 0.62-1.50). A latest CD4 count <100 cells/μl in HIV patients was not associated with higher MI risk (RR 0.96; 95% CI 0.62-1.50) but was associated with higher stroke risk (RR 2.26; 95% CI 1.29-3.94).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: