Key result
In a rat model of acute preload reduction, PAdP/dtmax properly reflected left ventricular systolic function until mean arterial pressure decreased below 40 mmHg.
Why the study?
Does PAdP/dtmax accurately reflect left ventricular systolic function during acute preload reduction in a rat model?
Does PAdP/dtmax accurately reflect left ventricular systolic function during acute preload reduction in a rat model?
PAdP/dtmax is a sensitive, continuous, load-independent contractility index that accurately reflects left ventricular systolic function even during large variations in preload.
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PAdP/dtmax shows promise as load-independent index in rat preload reduction; human validation required before clinical consideration.
Blaudszun et al. (2013) studied acute preload reduction (n=9). Preload-adjusted left ventricular dP/dtmax (PAdP/dtmax) vs. classical dP/dtmax-EDV and stroke work-EDV relationships was evaluated on Left ventricular systolic function during controlled haemorrhage. In a rat model of acute preload reduction, PAdP/dtmax properly reflected left ventricular systolic function until mean arterial pressure decreased below 40 mmHg.
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