March 22, 2018European Journal of Heart Failure
Are the Effects of Drugs to Prevent and to Treat Heart Failure Always Concordant? The Statin Paradox and its Implications for Understanding the Actions of Antidiabetic Medications
Key result
The distinction between HFrEF and HFpEF may explain why drugs like statins and antidiabetic medications have discordant effects in preventing versus treating heart failure.
Why the study?
Why do drugs like statins and antidiabetic medications have discordant effects in preventing versus treating heart failure, particularly between HFrEF and HFpEF?
Population
Patients with heart failure (HFrEF and HFpEF), obesity, and diabetes
Design
Review
Authors
Discussion
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Member takes
Implication
May inform phenotype-specific prevention in metabolic disease; leaves open targeted therapies for established HFrEF.
Structured PICO
Why do drugs like statins and antidiabetic medications have discordant effects in preventing versus treating heart failure, particularly between HFrEF and HFpEF?
P
Population
Patients with heart failure (HFrEF and HFpEF), obesity, and diabetes
I
Intervention
Statins, GLP-1 receptor agonists, and SGLT2 inhibitors
O
Outcome
Heart failure morbidity and mortality
The pathophysiological distinctions between HFrEF and HFpEF may explain why drugs that prevent heart failure in metabolic disorders (often HFpEF) may not be effective in treating established HFrEF.
Cite This Study
Milton Packer (2018) conducted a review in Heart failure. Statins and antidiabetic medications was evaluated. The distinction between HFrEF and HFpEF may explain why drugs like statins and antidiabetic medications have discordant effects in preventing versus treating heart failure.