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April 1, 1986Canadian Journal of Physiology and Pharmacology

Mapping of ventricular tachycardia induced by thoracic neural stimulation in dogs

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Why the study?

Does thoracic neural stimulation induce ventricular tachycardia in healthy canine myocardium?

Population

22 anesthetized open-chest dogs with healthy canine myocardium

Comparison

Electrical stimulation of sympathetic ganglia or… vs Stimulation of right-sided major cardiopulmonary…

Design

Preclinical

Authors

RCRené CardinalHôpital du Sacré-Cœur de MontréalPSP. SavardUniversity of TorontoJAJ. Andrew ArmourNorthwestern University

Discussion

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Implication

Sympathetic stimulation induces uniform VT from consistent posterior sites in healthy canine hearts; leaves open autonomic mechanisms in human ventricular arrhythmias.

Key Points

  • To investigate the characteristics and activation patterns of ventricular tachycardia induced by stimulating thoracic sympathetic ganglia and cardiac nerves in healthy hearts.
  • Conducted in anesthetized open-chest dogs (N=22) evaluating electrical stimulation across sympathetic ganglia and cardiopulmonary nerves.
  • Recorded surface ECGs simultaneously with 63 ventricular electrograms to generate off-line computer-derived isochronal and isopotential maps.
  • Ventricular tachycardia with uniform beat-to-beat morphology was induced in 13 of 22 dogs via stimulation of the left stellate ganglion (5 dogs), left middle cervical ganglion (4 dogs), left caudal pole nerve (2 dogs), or ventrolateral cardiac nerve (8 dogs), but not by right-sided stimulation.
  • Earliest electrical excitation typically localized to the posterior ventricular aspect with radial impulse spread; changes in initiation site or activation pattern altered QRS morphology.
  • Ventrolateral cardiac nerve stimulation significantly increased anterior and left-lateral potential gradients between positive and negative T waves, although these areas did not overlap with sites of earliest tachycardia excitation.

Structured PICO

Does thoracic neural stimulation induce ventricular tachycardia in healthy canine myocardium?

P
Population
22 anesthetized open-chest dogs with healthy canine myocardium
I
Intervention
Electrical stimulation of sympathetic ganglia or cardiac nerves (left stellate ganglion, left middle cervical ganglion, left caudal pole cardiopulmonary nerve, or ventrolateral cardiac nerve)
C
Comparator
Stimulation of right-sided major cardiopulmonary nerves or ganglia
O
Outcome
Induction and mapping of ventricular tachycardiasurrogate

The thoracic autonomic nervous system can induce repetitive ventricular excitation originating from consistent loci in healthy canine myocardium.

Cite This Study

Cardinal et al. (1986) studied this question.

synapsesocial.com/papers/6a19d084e7f8932c5eeaba2fhttps://doi.org/10.1139/y86-066
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac arrhythmias of sympathetic origin in the dog1977 · 11 citations
  2. 2Ventricular activation patterns of spontaneous and induced ventricular rhythms in canine one-day-old myocardial infarction. Evidence for focal and reentrant mechanisms.1982 · 172 citations
  3. 3Total Excitation of the Isolated Human Heart1970 · 1,790 citations
  4. 4Canine ventricular arrhythmias in the late myocardial infarction period. 8. Epicardial mapping of reentrant circuits.1981 · 256 citations
  5. 5The Pathway of Ventricular Depolarization in the Dog1956 · 153 citations