What question did this study set out to answer?

To characterize the clinical presentation, underlying risk factors, and therapeutic outcomes of disseminated bacille Calmette-Guérin (BCG) disease following vaccination.

June 1, 1997Clinical Infectious Diseases

Disseminated Bacille Calmette‐Guerin Disease After Vaccination: Case Report and Review

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To characterize the clinical presentation, underlying risk factors, and therapeutic outcomes of disseminated bacille Calmette-Guérin (BCG) disease following vaccination.
Analyzed one new clinical case alongside a retrospective review of 27 published cases identified from >5,000 literature reports between 1980 and 1996 (total N=28).
Evaluated patient demographics, immune status, vaccination history, treatment responses, and overall survival rates.
Underlying immune deficiency was present in 24 of 28 cases (85.7%), including 9 patients with AIDS, with 71% of all cases occurring in children younger than 2 years.
Treatment response was poor, resulting in an overall mortality rate of 71% across the cohort.
Disseminated disease expanded beyond infants to include older children and adults with HIV, as well as individuals revaccinated after anergic responses.

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Implication

Case series and literature review reveals high mortality from disseminated BCG disease in immunocompromised individuals, highlighting severe risks in HIV coinfection and revaccination.

Cite This Study

Talbot et al. (1997) studied this question.

synapsesocial.com/papers/6a19d29de7f8932c5eeabd62 https://doi.org/10.1086/513642

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Implication

Case series and literature review reveals high mortality from disseminated BCG disease in immunocompromised individuals, highlighting severe risks in HIV coinfection and revaccination.

Disseminated Bacille Calmette‐Guerin Disease After Vaccination: Case Report and Review

Key Points

Discussion

Implication

Cite This Study

Disseminated Bacille Calmette‐Guerin Disease After Vaccination: Case Report and Review

Key Points

Discussion

Implication

Cite This Study

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