Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 9, 2009Journal of Clinical OncologyOpen Access

Impact of Venous Thromboembolism and Anticoagulation on Cancer and Cancer Survival

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does anticoagulation therapy improve survival and exert antineoplastic effects in patients with cancer?

Population

Patients with cancer, including those without a venous thromboembolism (VTE) diagnosis

Design

Review

Authors

NKNicole M. KudererAdvanced DermatologyTOThomas L. OrtelUniversity of BergamoCFCharles W. FrancisVascular Medicine

Discussion

Loading...

Member takes

Implication

Should not change practice for cancer survival; leaves open antineoplastic LMWH effects pending definitive trials.

Structured PICO

Does anticoagulation therapy improve survival and exert antineoplastic effects in patients with cancer?

P
Population
Patients with cancer, including those without a venous thromboembolism (VTE) diagnosis
I
Intervention
Anticoagulation therapy (low molecular weight heparins [LMWH], unfractionated heparin, and vitamin K antagonists)
O
Outcome
Survival and antineoplastic effects (tumor progression, invasion, angiogenesis, and metastasis formation)

Anticoagulation, particularly with LMWH, holds promise for improving survival in cancer patients through potential antineoplastic mechanisms, but definitive large-scale trials are needed to confirm efficacy and safety.

Limitations

  • Definitive clinical trials have been elusive
  • Questions remain regarding the importance of tumor type and stage on treatment efficacy
  • Unclear impact of fatal thromboembolic events
  • Optimal anticoagulation therapy is not yet defined
  • Safety with differing chemotherapy regimens remains a question

Cite This Study

Kuderer et al. (2009) studied this question.

synapsesocial.com/papers/6a19da93196cd56b09ead077https://doi.org/10.1200/jco.2009.22.4584

Topics

Anticoagulation in AF
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-Molecular-Weight Heparin and Cancer Survival: Review of the Literature and Pooled Analysis of 1,726 Patients Treated for at Least Three Months2003 · 28 citations
  2. 2The Risk of a Diagnosis of Cancer after Primary Deep Venous Thrombosis or Pulmonary Embolism1998 · 627 citations
  3. 3Basic-Fibroblast-Growth-Factor-Mediated de novo Angiogenesis Is More Effectively Suppressed by Low-Molecular-Weight than by High-Molecular-Weight Heparin2008 · 65 citations
  4. 4Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis2000 · 172 citations
  5. 5Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation1987 · 76 citations