Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states.
Why the study?
Does a new functional assay for protein C better reflect anticoagulant activity compared to amidolytic or immunologic levels in patients on oral anticoagulation or with specific disease states?
Population
Patients on oral anticoagulation, patients with liver failure, disseminated intravascular coagulation, and…
Comparison
Measurement of protein C using a new functional… vs Measurement of protein C using amidolytic or…
Design
Other
Authors
Discussion
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Member takes
Implication
May require functional over antigenic protein C assays on warfarin; leaves open validation across coagulopathies.
Structured PICO
Does a new functional assay for protein C better reflect anticoagulant activity compared to amidolytic or immunologic levels in patients on oral anticoagulation or with specific disease states?
P
Population
Patients on oral anticoagulation (warfarin), patients with liver failure, disseminated intravascular coagulation (DIC), and thromboembolic disease (including 2 specific patients identified).
I
Intervention
Measurement of protein C using a new functional assay involving adsorption on a Ca+2-dependent monoclonal antibody, elution, quantitative activation, and assessment of plasma anticoagulant activity.
C
Comparator
Measurement of protein C using amidolytic or immunologic assays.
O
Outcome
Correlation between functional protein C anticoagulant activity and amidolytic or immunologic levels.surrogate
A new functional assay for protein C reveals that functional activity decreases more than antigenic levels during oral anticoagulation, identifying a new class of protein C-deficient individuals.
Cite This Study
D’Angelo et al. (1986) studied this question.