Key result
Observed-to-expected protein C and S ratios successfully identify deficient patients taking warfarin.
Why the study?
Protein S deficiency has not been addressed by ratio calculation methods during oral anticoagulant therapy, unlike protein C deficiency.
Can ratio calculations of protein C and protein S to procoagulant factors identify deficient patients during oral anticoagulant therapy?
Population
Normal blood donors and patients on stabilized warfarin therapy including known protein C and protein S deficient patients
Comparison
Observed over expected protein C and protein S values dependent on FVII and FII levels versus normal ranges
Design
Observational study comparing functional and antigenic determinations with procoagulant factors
Authors
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May support ratio-based detection of protein S deficiency on warfarin; leaves open validation in prospective cohorts.
Observational
Can ratio calculations of protein C and protein S to procoagulant factors identify deficient patients during oral anticoagulant therapy?
Ratio calculations of protein C and protein S to procoagulant factors can successfully identify deficient patients even while they are on stabilized warfarin therapy.
O’Brien et al. (1998) conducted an observational in Protein C and protein S deficiency during oral anticoagulant therapy. Ratio calculation of protein C and protein S to Factors VII and II was evaluated on Identification of known protein C and protein S deficient patients. Calculation of observed over expected protein C and protein S ratios successfully identified known protein C and protein S deficient patients taking warfarin.
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