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December 13, 1984New England Journal of Medicine

Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S

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Why the study?

Is protein S deficiency associated with recurrent venous thrombosis?

Population

6 unrelated persons with severe recurrent venous thrombosis

Comparison

Determination of protein S levels using a… vs Normal persons

Design

Case_series

Discussion

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Overview

Protein S deficiency was associated with recurrent venous thrombosis; hypothesis-generating and does not support routine testing.

Structured PICO

Is protein S deficiency associated with recurrent venous thrombosis?

P
Population
6 unrelated persons with severe recurrent venous thrombosis
I
Intervention
Determination of protein S levels using a functional assay
C
Comparator
Normal persons (protein S activity 63 to 160 per cent)
O
Outcome
Protein S deficiency levelssurrogate

Protein S deficiency is associated with severe recurrent venous thrombosis, suggesting that measuring protein S levels is useful in evaluating these patients.

Cite This Study

A 1984 study studied this question.

synapsesocial.com/papers/6a80bb2573f13514bdeedf1bhttps://doi.org/10.1056/nejm198412133112401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.1976 · 628 citations
  2. 2Deficiency of protein C in congenital thrombotic disease.1981 · 1,263 citations
  3. 3Familial protein S deficiency is associated with recurrent thrombosis.1984 · 603 citations
  4. 4A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S1977 · 585 citations
  5. 5Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V1984 · 230 citations