Key result
Free protein S deficiency (< 53 U/dL) was not associated with venous thrombosis in a population-based case-control study (OR 0.82; 95% CI 0.56-1.21).
Why the study?
Is protein S deficiency associated with an increased risk of venous thrombosis in the general population?
Population
5,317 subjects in a population-based case-control study (MEGA study) evaluating venous thrombosis.
Comparison
Protein S deficiency and PROS1 mutations vs Normal protein S levels
Design
Case-control
Authors
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Free protein S deficiency <53 U/dL was not associated with venous thrombosis; leaves open severe deficiency risk and does not support unselected testing.
Case-Control (n=5,317)
Is protein S deficiency associated with an increased risk of venous thrombosis in the general population?
Odds Ratio: 0.82 (95% CI 0.56–1.21)
Inherited protein S deficiency is rare in the general population, and routine protein S or PROS1 testing should not be considered in unselected patients with venous thrombosis.
Pintão et al. (2013) conducted a case-control in venous thrombosis (n=5,317). Free protein S deficiency (< 53 U/dL) vs. Normal free protein S levels was evaluated on venous thrombosis (OR 0.82, 95% CI 0.56-1.21). Free protein S deficiency (< 53 U/dL) was not associated with venous thrombosis in a population-based case-control study (OR 0.82; 95% CI 0.56-1.21).
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