Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) see comments
Why the study?
Does protein C deficiency increase the risk of venous thrombosis in the general outpatient population?
Population
948 subjects: 474 consecutive outpatients aged <70 years with a first objectively diagnosed episode of…
Comparison
Protein C deficiency, antithrombin deficiency… vs Normal levels of Protein C, antithrombin, and…
Design
Case-control
Authors
Discussion
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Implication
Supports protein C deficiency evaluation in outpatients; extends case-control evidence but leaves open prospective trials for management changes.
Structured PICO
Does protein C deficiency increase the risk of venous thrombosis in the general outpatient population?
P
Population
948 subjects: 474 consecutive outpatients aged <70 years with a first objectively diagnosed episode of venous thrombosis without underlying malignant disease, and 474 healthy controls matched for age and sex.
I
Intervention
Protein C deficiency (PC activity <0.67 U/mL or PC antigen <0.33 U/mL when using coumarins), antithrombin deficiency, or protein S deficiency
C
Comparator
Normal levels of Protein C, antithrombin, and protein S
O
Outcome
First episode of venous thrombosishard clinical
Protein C and antithrombin deficiencies, although infrequent in the general population, are clear risk factors for a first episode of venous thrombosis.
Cite This Study
Koster et al. (1995) studied this question.