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January 1, 1999Thrombosis and Haemostasis

Hormonal State rather than Age Influences Cut-off Values of Protein S: Reevaluation of the Thrombotic Risk Associated with Protein S Deficiency

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Why the study?

Does protein S deficiency, defined by hormonal state-adjusted cut-offs, increase the risk of thrombosis?

Population

474 healthy control subjects of the Leiden Thrombophilia Study used to establish cut-offs, and patients in…

Comparison

Protein S deficiency defined by specific cut-off… vs Normal protein S levels

Design

Case-control

Authors

GLG. Di LibertiFondazione IRCCS Istituto Nazionale dei TumoriRBR M BertinaLeiden UniversityFRF. R. RosendaalLeiden University Medical Center

Discussion

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Implication

Adjusted cut-offs suggest protein S deficiency may not raise thrombosis risk; challenges prior associations and leaves open prospective validation.

Structured PICO

Does protein S deficiency, defined by hormonal state-adjusted cut-offs, increase the risk of thrombosis?

P
Population
474 healthy control subjects of the Leiden Thrombophilia Study (LETS) used to establish cut-offs, and patients in the LETS study to evaluate thrombotic risk
I
Intervention
Protein S deficiency (total or free) defined by specific cut-off points adjusted for menopausal state and oral contraceptive use
C
Comparator
Normal protein S levels
O
Outcome
Risk of thrombosishard clinical

Adjusting protein S cut-off values for hormonal state rather than age reveals no significant increase in thrombotic risk associated with protein S deficiency in this cohort.

Cite This Study

Liberti et al. (1999) studied this question.

synapsesocial.com/papers/6a8be328eada60f85de3cf3ahttps://doi.org/10.1055/s-0037-1614334
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study2013 · 107 citations
  2. 2Hereditary Protein S Deficiency and Venous Thrombo-Embolism1985 · 74 citations
  3. 3Associations of protein C and protein S with serum lipid concentrations1998 · 22 citations
  4. 4Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S2000 · 135 citations
  5. 5Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) [see comments]1995 · 371 citations