Key result
Oxidative stress drives endothelial dysfunction and atherosclerosis by promoting vascular inflammation and injury.
Why the study?
Inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression, and complications, motivating a review of how oxidative stress links to vascular dysfunction and ischemic heart disease.
Oxidative stress and inflammation are key pathophysiological drivers of endothelial dysfunction and atherosclerosis in ischemic heart disease.
Reinforces oxidative stress as a therapeutic target in IHD; supports consensus but leaves clinical translation of antioxidants open.
One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative stress, oxidation, and antioxidant systems have been elucidated, and numerous important pathophysiological links to na number of disorders and diseases have been established. This review article will present the most relevant knowledge linking oxidative stress to vascular dysfunction and disease. The review will focus on the role of oxidative stress in endotheleial dysfunction, atherosclerosis, and other pathogenetic processes and mechanisms that contribute to the development of ischemic heart disease.
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Kibel et al. (2020) conducted a review in Ischemic Heart Disease and Atherosclerosis. Oxidative stress was evaluated. Oxidative stress plays a crucial role in the pathogenesis of endothelial dysfunction, atherosclerosis, and ischemic heart disease by promoting inflammation and vascular injury.
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