Key result
Oxidative stress is a potent inductor of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution.
Oxidative stress is a potent inductor of endothelial dysfunction and is involved in all stages of atherosclerotic plaque evolution.
Oxidative stress modulation merits exploration in atherosclerosis; leaves open whether targeted therapies improve clinical outcomes.
O ver the last decades, sound evidence has been generated that oxidative stress is one of the most potent inductors of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution.1,2 Experimental and animal models provide a clear association between the amount of oxidative challenge and reversible vascular dysfunction that can be observed before permanent alterations of the vessel wall occur.
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Schnabel et al. (2007) conducted a review in Cardiovascular Disease. Oxidative stress was evaluated. Oxidative stress is a potent inductor of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution.
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