Key result
The Guide to Pharmacology database version 2021.3 provides an expert-driven citation summary and reference list for the voltage-gated potassium channel (Kv) family and its subunits.
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Updates expert-curated Kv channel data; extends prior guides but leaves open direct clinical application.
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
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Attali et al. (2021) studied this question. The Guide to Pharmacology database version 2021.3 provides an expert-driven citation summary and reference list for the voltage-gated potassium channel (Kv) family and its subunits.
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