Key result
The IUPHAR/BPS Guide to Pharmacology Database provides an expert-driven citation summary and reference guide for voltage-gated potassium channels and their pharmacological targets.
Provides a citation summary and database links for voltage-gated potassium channels in the IUPHAR/BPS Guide to Pharmacology Database.
Provides expert-curated K+ channel pharmacology resource; leaves open clinical translation pending prospective trials.
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
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Attali et al. (2019) studied Voltage-gated potassium channels. The IUPHAR/BPS Guide to Pharmacology Database provides an expert-driven citation summary and reference guide for voltage-gated potassium channels and their pharmacological targets.
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