Why the study?
Is there an interconnection between hyperleptinemia, quality of life, and severity of metabolic disorders in patients with essential hypertension and metabolic syndrome?
Is there an interconnection between hyperleptinemia, quality of life, and severity of metabolic disorders in patients with essential hypertension and metabolic syndrome?
Higher serum leptin levels are inversely correlated with quality of life in patients with essential hypertension and metabolic syndrome.
Higher leptin associated with poorer QOL in essential hypertension plus metabolic syndrome; hypothesis-generating, does not support practice change.
Objective. To study interconnection between hyperleptinemia, the quality of life (QOL) and the severity of metabolic disorders in patients with essential hypertension with metabolic syndrome (MS). Design and methods.We have examined 46 patients with essential hypertension (blood pressure < 180/110 mm Hg), accompanied by MS. Along with complete clinical, laboratory and instrumental examination, customary in a specialized cardiologic clinic, the QOL research was carried out using MOS SF-36questionnaire. Besides, the concentration of leptin in blood serum was determined. Results and conclusions. Patients with essential hypertension with hyperleptinemia show higher intensity of clinical and laboratory markers of MS, higher activity of the systemic inlammatory response and increased QOL. A statistically signiicant inverse correlation between serum leptin level and QOL scales (SF-36) was detected.
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Беспалова et al. (2013) studied this question.
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