February 8, 2013The Journal of Clinical Endocrinology & Metabolism
Experimental Hyperleptinemia Acutely Increases Vasoconstrictory Sympathetic Nerve Activity in Healthy Humans
Why the study?
Does an IV bolus of leptin increase muscle sympathetic nerve activity in healthy normal-weight males?
Population
12 healthy normal-weight males
Comparison
IV bolus of leptin vs Placebo (crossover design)
Design
RCT, balanced crossover design, double-blind
Follow-up
140 minutes
Authors
Discussion
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Member takes
Implication
No immediate clinical implications for leptin use; leaves open its causal role in obesity-related sympathetic activation and hypertension.
Structured PICO
Does an IV bolus of leptin increase muscle sympathetic nerve activity in healthy normal-weight males?
P
Population
12 healthy normal-weight males
I
Intervention
IV bolus of leptin
C
Comparator
Placebo (crossover design)
O
Outcome
Muscle sympathetic nerve activity (MSNA) measured in bursts per minute continuously recorded using a microneurographic technique up to 140 minutes after administrationsurrogate
Acute experimental hyperleptinemia significantly increases vasoconstrictory sympathetic outflow in healthy men, suggesting leptin may link obesity to elevated sympathetic nerve activity and hypertension.
Cite This Study
Machleidt et al. (2013) studied this question.