Why the study?
What are the determinants of diastolic dysfunction in patients with newly recognized, untreated systemic hypertension?
What are the determinants of diastolic dysfunction in patients with newly recognized, untreated systemic hypertension?
In newly diagnosed, untreated hypertension, age and impaired baroreflex sensitivity, rather than blood pressure levels, are the primary determinants of left ventricular diastolic dysfunction.
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Reduced baroreflex gain may predict diastolic dysfunction beyond BP in new hypertension; leaves open causal mechanisms and intervention targets.
Pitzalis et al. (1999) studied this question.
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