Why the study?
Does perindopril or bisoprolol prevent trastuzumab-mediated left ventricular remodeling in patients with HER2+ early breast cancer?
Population
159 patients with histologically confirmed HER2+ early breast cancer treated with adjuvant trastuzumab…
Comparison
Perindopril or bisoprolol administered for 1… vs Matching placebo administered for 1 year…
Design
RCT, 1:1:1 ratio using a secure internet randomization service, Double-blind
Follow-up
24 months
Authors
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The MANTICORE 101 - Breast trial is designed to provide first randomized evidence on whether prophylactic perindopril or bisoprolol can prevent trastuzumab-induced left ventricular remodeling in patients with HER2+ early breast cancer.
Does perindopril or bisoprolol prevent trastuzumab-mediated left ventricular remodeling in patients with HER2+ early breast cancer?
The MANTICORE 101 - Breast trial is designed to provide first randomized evidence on whether prophylactic perindopril or bisoprolol can prevent trastuzumab-induced left ventricular remodeling in patients with HER2+ early breast cancer.
Pituskin et al. (2011) studied this question.
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