Key result
Sertraline and citalopram/escitalopram are safer to use with warfarin, whereas fluoxetine and fluvoxamine have a higher interaction potential for bleeding.
Why the study?
Warfarin has a narrow therapeutic index, making interactions with antidepressants potentially severe, and it is unclear whether clinicians have sufficient knowledge about the associated bleeding risk.
What is the risk of bleeding and interaction potential when antidepressants are used concomitantly with warfarin?
Comparison
Warfarin and concomitant antidepressants
Design
Systematic review
Authors
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Supports preferring sertraline or citalopram/escitalopram with warfarin; confirms SSRI-specific bleeding risks in systematic evidence.
Systematic Review
What is the risk of bleeding and interaction potential when antidepressants are used concomitantly with warfarin?
Sertraline and citalopram/escitalopram are preferred antidepressants for patients on warfarin due to lower interaction potential compared to fluoxetine and fluvoxamine.
Korkmaz et al. (2020) conducted a systematic review in Warfarin-antidepressant interactions. Antidepressants was evaluated on Bleeding risk and interaction potential. Sertraline and citalopram/escitalopram are safer to use with warfarin, whereas fluoxetine and fluvoxamine have a higher interaction potential for bleeding.
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