Why the study?
The thrombogenicity of disrupted atherosclerotic lesions depends on plaque components and tissue factor's role in this process needed examination.
Comparison
Different types of atherosclerotic plaques and their components
Design
Ex vivo perfusion study using Badimon chamber with heparinized blood and 111In-labeled platelets
Authors
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Lipid-rich plaques exhibit highest thrombogenicity tied to tissue factor content; hypothesis-generating for targeted inhibition after disruption.
Key points are not available for this paper at this time.
Toschi et al. (1997) studied this question.
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