Key result
Novel ultrasound-Doppler device estimates AT/ET ratio from carotid distension with ~0.8 correlation to LVOT flow.
Why the study?
Non-invasive assessment of LV function is crucial for early cardiovascular disease management, leading researchers to explore the feasibility of a novel device for surrogate AT/ET ratio estimation using carotid artery distension dynamics.
Does a custom-designed device combining A-mode ultrasound and pocket Doppler accurately estimate the AT/ET ratio compared to LVOT flow in healthy young males?
Observational (n=17)
Does a custom-designed device combining A-mode ultrasound and pocket Doppler accurately estimate the AT/ET ratio compared to LVOT flow in healthy young males?
A novel portable device combining A-mode ultrasound and pocket Doppler can accurately estimate the LV contractility surrogate AT/ET ratio from carotid artery distension in healthy young males.
May support portable carotid AT/ET assessment; hypothesis-generating in healthy young males and requires prospective validation.
Non-invasive assessment of left ventricular (LV) function is crucial for early diagnosis and management of cardiovascular diseases. The Acceleration Time (AT) to Ejection Time (ET) ratio, is a measurement used to assess the contractility of the left ventricle (LV) of the heart. This study explores the feasibility of a novel device for a surrogate estimation of the AT/ET ratio using carotid artery distension dynamics. In this in-vivo study, 17 healthy young male participants were recruited. A custom-designed device combining A-mode ultrasound and a pocket Doppler was used to acquire simultaneous measurements of carotid artery distension and blood flow velocity. The pocket Doppler aided in identifying critical events in the carotid artery flow waveform, serving as reference points for analyzing the second derivative of the carotid distension waveform obtained by the A-mode component. This facilitated the estimation of surrogate AT, ET, and the AT/ET ratio from carotid artery dynamics. The study demonstrated a strong correlation between surrogate markers and reference measurements. The surrogate AT measured from carotid distension showed a significant correlation (r = 0.81, p < 0.05) with the reference AT obtained from LVOT flow. Similarly, the surrogate ET derived from carotid distension exhibited a strong correlation (r = 0.83, p < 0.05) with the reference ET from LVOT. Importantly, the surrogate AT/ET ratio estimated from carotid artery dynamics displayed a significant correlation (r = 0.8, p < 0.05) with the reference AT/ET ratio measured using the gold-standard LVOT flow waveform. This study suggests that the combined A-mode ultrasound and pocket Doppler device has the potential to serve as a non-invasive tool for estimating key LV function parameters, including the clinically relevant AT/ET ratio, through analysis of carotid artery distension. Further research with a larger and more diverse population is warranted to validate this approach for broader clinical applications.
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Jaganathan et al. (2024) conducted an observational in Healthy (n=17). Custom-designed device combining A-mode ultrasound and a pocket Doppler vs. Reference measurements from LVOT flow was evaluated on Correlation of surrogate AT/ET ratio with reference AT/ET ratio (r = 0.8, p=< 0.05). A novel device combining A-mode ultrasound and pocket Doppler estimated the AT/ET ratio from carotid artery distension with strong correlation to the gold-standard LVOT flow waveform (r=0.8, p<0.05).
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