What does this research mean for the field?

A normally functioning bradykinin B2-receptor is essential for maintaining cardiovascular homeostasis, as its disruption in mice leads to elevated basal blood pressure, cardiac hypertrophy, and increased sensitivity to angiotensin II and salt loading. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 18, 1997Circulation

Cardiovascular Phenotype of a Mouse Strain With Disruption of Bradykinin B₂-Receptor Gene

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Why the study?

Does disruption of the bradykinin B2-receptor gene alter blood pressure and cardiovascular homeostasis in mice?

Structured PICO

Does disruption of the bradykinin B2-receptor gene alter blood pressure and cardiovascular homeostasis in mice?

Population

Mouse strain with disruption of the bradykinin B2-receptor gene (Bk2r-/-), wild-type Bk2r+/+, and heterozygous Bk2r+/- mice

Intervention

Genetic disruption of the bradykinin B2-receptor gene (Bk2r-/-), with additional pharmacological challenges (Icatibant, nitro-L-arginine-methyl ester, angiotensin AT1-receptor antagonist, chronic salt loading)

Comparator

Wild-type Bk2r+/+ and heterozygous Bk2r+/- mice

Outcome

Basal blood pressure and heart weightsurrogate

Disruption of the bradykinin B2-receptor gene in mice leads to elevated basal blood pressure and increased heart weight, indicating its essential role in cardiovascular homeostasis.

Authors

PMPaolo MadedduUniversity of Sassari MVMaria Vittoria VaroniUniversity of Sassari DPDomenico PalombaUniversity of Sassari

Discussion

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Implication

Preclinical B2-receptor disruption affects mouse BP homeostasis; leaves open human relevance and requires translational validation.

Cite This Study

Madeddu et al. (1997) studied this question.

synapsesocial.com/papers/6a1a0eba05af093a17f6efde https://doi.org/10.1161/01.cir.96.10.3570

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Cardiovascular Phenotype of a Mouse Strain With Disruption of Bradykinin B₂-Receptor Gene

Structured PICO

Discussion

Implication

Cite This Study

Cardiovascular Phenotype of a Mouse Strain With Disruption of Bradykinin B₂-Receptor Gene

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider