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March 1, 2001HypertensionOpen Access

Angiotensin II–Induced Hypertension in Bradykinin B 2 Receptor Knockout Mice

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Population

Bradykinin B2 receptor knockout (B2R-/-) and wild-type (B2R+/+) mice weighing 22 to 26 g

Comparison

Angiotensin II or norepinephrine infusion via… vs Saline infusion via osmotic minipump

Design

Preclinical

Follow-up

12 to 13 days

Authors

LČLuděk ČervenkaCross-Cutting CardiologyJMJan MalýUniversity Hospital Hradec KrálovéLKL KarasováNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Discussion

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Implication

B2R deletion worsens Ang II hypertension in mice; hypothesis-generating for kinin system role in human hypertension.

Structured PICO

P
Population
Bradykinin B2 receptor knockout (B2R-/-) and wild-type (B2R+/+) mice weighing 22 to 26 g
I
Intervention
Angiotensin II (40 ng/min) or norepinephrine (45 ng/min) infusion via intraperitoneally implanted osmotic minipump
C
Comparator
Saline infusion via osmotic minipump
O
Outcome
Systolic blood pressure (SBP) measured by tail-cuff plethysmography on day 12 after implantationsurrogate

The kallikrein-kinin system selectively buffers the vasoconstrictor activity of Angiotensin II, likely through NO release mediated by endogenous kinins.

Cite This Study

Červenka et al. (2001) studied this question.

synapsesocial.com/papers/6a8384fd6524aee222604f12https://doi.org/10.1161/01.hyp.37.3.967

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation1999 · 565 citations
  2. 2Regulation of Angiotensin II Type 1 Receptor mRNA and Protein in Angiotensin II–Induced Hypertension1999 · 90 citations
  3. 3Renin, Angiotensinogen, and Kallikrein Gene Expression in Two-Kidney Goldblatt Hypertensive Rats1993 · 50 citations
  4. 4Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function2000 · 433 citations
  5. 5Modulation of Extracellular Superoxide Dismutase Expression by Angiotensin II and Hypertension1999 · 192 citations