Key result
A lower aldosterone/renin ratio (OR 0.73) and higher soluble ACE2 levels (OR 1.33) were independently associated with severe COVID-19, defined as ICU admission or death.
Why the study?
COVID-19 severity is unpredictable, prompting investigation into determinants of severity with a focus on RAAS components and genetic variations in ACE2 and TMPRSS2.
Do soluble ACE2 levels, aldosterone/renin ratio, and TMPRSS2 polymorphisms predict disease severity in adults hospitalized with COVID-19?
Population
188 adult patients hospitalized due to SARS-CoV-2 infection
Comparison
Severe COVID-19 (ICU and/or death) vs non-severe COVID-19
Design
Observational study
Authors
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May support risk stratification in hospitalized COVID-19; hypothesis-generating for RAAS pathways, requiring prospective validation.
Observational (n=188)
No
Do soluble ACE2 levels, aldosterone/renin ratio, and TMPRSS2 polymorphisms predict disease severity in adults hospitalized with COVID-19?
Effect estimate: OR 0.73 (95% CI 0.59-0.89)
p-value: p=0.0037
High soluble ACE2, a low aldosterone/renin ratio, and the TMPRSS2 rs2070788 non-AA genotype are independent predictors of severe COVID-19, independent of RAAS blocker use.
Akın et al. (2021) conducted an observational in COVID-19 (n=188). Aldosterone/Renin ratio was evaluated on Severe COVID-19 (ICU admission and/or all-cause death) (OR 0.73, 95% CI 0.59-0.89, p=0.0037). A lower aldosterone/renin ratio (OR 0.73) and higher soluble ACE2 levels (OR 1.33) were independently associated with severe COVID-19, defined as ICU admission or death.
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