Key result
Presence of Q waves prior to discharge in STEMI patients treated with fibrinolysis was associated with increased odds of cardiovascular death or CHF at 30 days (adjusted OR 2.08, P ≤ 0.001).
Why the study?
Does the presence of pathologic Q waves predict worse reperfusion and increased 30-day cardiovascular events in STEMI patients treated with fibrinolysis?
RCT (n=3,491)
placebo-controlled
randomized
Does the presence of pathologic Q waves predict worse reperfusion and increased 30-day cardiovascular events in STEMI patients treated with fibrinolysis?
Effect estimate: ORadj 2.08
p-value: p=≤ 0.001
The presence of Q waves prior to discharge in STEMI patients treated with fibrinolysis is a simple marker for less successful reperfusion and higher risk of 30-day cardiovascular events.
No takes yet. Share an insight, caveat, or question.
Q waves may aid post-fibrinolysis risk stratification in STEMI; extends prior observations but leaves open prospective validation.
Waks et al. (2014) conducted an RCT in ST-elevation myocardial infarction (STEMI) (n=3,491). clopidogrel vs. placebo was evaluated on composite of cardiovascular death/CHF at 30 days (ORadj 2.08, p=≤ 0.001). Presence of Q waves prior to discharge in STEMI patients treated with fibrinolysis was associated with increased odds of cardiovascular death or CHF at 30 days (adjusted OR 2.08, P ≤ 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: