Key result
Hormone replacement therapy in postmenopausal women significantly improved the ratio of peak early to late diastolic filling velocity compared with placebo (MD 0.20; 95% CI 0.12 to 0.28).
Why the study?
Postmenopausal women experience changes in left ventricular diastolic function, but reports regarding the effects of hormone replacement therapy on diastolic function have been conflicting.
Does hormone replacement therapy improve left ventricular diastolic function in postmenopausal women?
Meta-Analysis (n=668)
Does hormone replacement therapy improve left ventricular diastolic function in postmenopausal women?
Hormone replacement therapy appears to have beneficial effects on echocardiographic parameters of left ventricular diastolic function in postmenopausal women.
Answers are grounded in this paper and cite their sources.
HRT improves E/A ratio in postmenopausal women; extends meta-analytic evidence for LV diastolic benefits and supports targeted trials.
BACKGROUND: Postmenopausal women tend to experience significant changes in left ventricular diastolic function (LVDF). However, there are conflicting reports about LVDF between postmenopausal women on hormone replacement therapy (HRT) and those not on HRT. This meta-analysis is to evaluate the effects of HRT on LVDF in postmenopausal women. METHODS: We conducted a systemic review of randomized controlled trials published up to December 31 2019 using Embase, Pubmed, and the Cochrane library database. RESULTS: Eight studies involving 668 postmenopausal women were identified. Our analysis indicated that the ratio of the peak velocity during early filing to late filling from atrial contraction improvement in HRT group was better than that in placebo group (MD 0.20, 95%CI 0.12 to 0.28). There was a significant reduction in deceleration time and left ventricular mass index in HRT group compared with placebo group (MD -21.01, 95%CI -40.11 to -1.91 vs MD -8.26, 95%CI -14.10 to -2.42). No significant difference was observed in left ventricular end systole diameter (MD 0.80, 95%CI -0.72 to 2.31), left ventricular end diastole diameter (MD -0.07, 95%CI -1.25 to 1.10), left atrial size (MD -0.33, 95%CI -1.34 to 0.68)and the isovolumic relaxation time (MD -12.08, 95%CI -27.65 to 3.5). CONCLUSIONS: Our meta-analysis illustrated that postmenopausal women seem to obtain more beneficial effects from HRT on LVDF, though future studies are required to elucidate the specific mechanisms for this phenomenon.
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Chen et al. (2020) conducted a meta-analysis in Postmenopausal women (n=668). Hormone replacement therapy vs. Placebo was evaluated on Ratio of the peak velocity during early filing to late filling from atrial contraction (MD 0.20, 95% CI 0.12 to 0.28). Hormone replacement therapy in postmenopausal women significantly improved the ratio of peak early to late diastolic filling velocity compared with placebo (MD 0.20; 95% CI 0.12 to 0.28).
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