Key result
Oestradiol improves LV diastolic function, reducing isovolumic relaxation time by ~21 ms vs placebo.
Why the study?
There are conflicting reports about the effects of oestrogen on left ventricular diastolic function in postmenopausal women.
Does oestradiol improve left ventricular diastolic function in hypertensive postmenopausal women with left ventricular diastolic dysfunction?
RCT (n=34)
Double-blind
randomised
Does oestradiol improve left ventricular diastolic function in hypertensive postmenopausal women with left ventricular diastolic dysfunction?
p-value: p=< 0.001
Chronic (12-week) administration of physiological doses of oestradiol significantly improves left ventricular diastolic function in hypertensive postmenopausal women with diastolic dysfunction, whereas acute administration has no effect.
No takes yet. Share an insight, caveat, or question.
Supports short-term oestradiol for LV diastolic dysfunction in hypertensive postmenopausal women; extends RCT evidence on estrogen's cardiac effects.
Israel Nunes Alecrin (2004) conducted an RCT in hypertensive postmenopausal women with left ventricular diastolic dysfunction (n=34). oestradiol vs. placebo was evaluated on isovolumic relaxation time (p=< 0.001). Oestradiol 1 mg/day for 12 weeks significantly improved left ventricular diastolic function, decreasing isovolumic relaxation time from 127 to 106 ms (p<0.001).
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