Key result
Acute oestrogen improves systolic performance and lowers vascular resistance in men with advanced CHF.
Why the study?
Does acute oestrogen infusion improve haemodynamics in male patients with advanced chronic heart failure?
Population
15 men with advanced chronic heart failure (NYHA II-IV, EF < 35%)
Comparison
Acute oestrogen infusion (0.625 and 1.25 mg) vs Baseline and placebo administration
Design
Other
Follow-up
Acute (during infusion)
Authors
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May warrant randomized trials of acute oestrogen in advanced HF; leaves open any clinical role.
Does acute oestrogen infusion improve haemodynamics in male patients with advanced chronic heart failure?
Acute oestrogen administration improves indices of cardiac systolic performance and decreases pulmonary and systemic vascular resistance in men with advanced heart failure.
Adamopoulos et al. (2002) studied chronic heart failure (n=15). Oestrogen vs. Baseline and placebo was evaluated on Central haemodynamics and limb plethysmography. Acute oestrogen administration in men with advanced chronic heart failure improved cardiac systolic performance and decreased pulmonary and systemic vascular resistance.
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