Observational surveillance reveals high frequencies of dihydropteroate synthase resistance mutations in malaria patients, suggesting compromised sulfadoxine efficacy.
Background: ) gene in two health facilities in the Mbouda Health District, Cameroon. Methodology: to detect the A437G and A581G mutations, respectively. Results: = 0.001), with the highest prevalence among participants with primary education only (41.66%) and the lowest among those with no formal schooling (10.34%). The frequency of the A581G mutant allele was 67.60%, while that of A437G was 45.07%. The wild-type allele frequencies were 48.87% for A437G and 22.53% for A581G. Mixed alleles were observed only for A437G (1.40%). Conclusion: mutations associated with pyrimethamine resistance were not assessed, overall sulfadoxine-pyrimethamine efficacy cannot be conclusively determined.
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