Exploring the landscape of exosomes in heart failure: a bibliometric analysis

Figure 1.. Flowchart for search process.

Figure 2.. Global publication distribution and citation trends. (A) Geographic publication distribution of exosomes in HF. (B) Trends in the publications of exosomes in HF.

Figure 3.. Distribution of publications and citations in country and institution. (A) Number of publications and citations by the top 10 countries. (B) Connections between publications from different countries. (C) Number of publications and citations by the top 10 institutions. (D) Connections between publications from different institutions. PCSHE: Pennsylvania Commonwealth System of Higher Education. INSERM: Institut National De La Sante Et De La Recherche Medicale.

Figure 4.. Visualization of co-authors and co-cited journals. (A) Co-cited authors collaboration network on exosomes in HF. (B) Co-cited journal network on exosomes in HF.

Figure 5.. Hot keywords on exosomes in HF. (A) Co-cited network on exosomes in HF by VOSviewer. (B) Clustering on exosomes in HF keywords by CiteSpace. (C) Time clustering on exosomes in HF by CiteSpace. (D) Top 25 keywords with the strongest citation burst by CiteSpace.

Figure 6.. Hot references on exosomes in HF. (A) Co-occurrence network of co-cited references on exosomes in HF by VOSviewer. (B) Clustering of references on exosomes in HF. (C) Time clustering of references on exosomes in HF by CiteSpace. (D) Top 25 references with the strongest citation bursts by CiteSpace.

Figure 7.. Function of MSC-derived exosomes in the treatment of heart failure. Exosomes can be isolated from mesenchymal stem cell supernatant by gradient centrifugation. Exosomes are secreted into the bull’s eye and blood vessels, exerting a significant inhibitory effect on cardiomyocyte apoptosis, immune cell infiltration and cardiac remodeling, and promoting angiogenesis during tissue repair. The figure was created by BioRender (www.biorender.com).