What does this research mean for the field?

While overall tricuspid transcatheter edge-to-edge repair (TEER) does not significantly alter renal or liver function, successful TEER resulting in moderate or less tricuspid regurgitation leads to small but significant improvements in eGFR and MELD-XI scores. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess how renal and liver function affect outcomes after tricuspid valve repair.

May 30, 2026Journal of the American College of Cardiology

Impact of Renal and Liver Function on Clinical Outcomes Following Tricuspid Valve Transcatheter Edge-to-Edge Repair

Q: What are the key findings of this study?

Tricuspid transcatheter edge-to-edge repair did not significantly change overall eGFR or MELD-XI, but successful TEER improved eGFR (+3.55 vs 0.07, p=0.022) and MELD-XI (-0.52 vs 0.34, p=0.0007).

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Severe tricuspid regurgitation (TR) (n=572). Intervention: Tricuspid transcatheter edge-to-edge repair (TEER) + medical therapy vs. Medical therapy alone. Primary outcome: Changes in eGFR and MELD-XI at 12 months.

View Full Paper

Ask AI

Bookmark

Key result

Tricuspid TEER yields no overall end-organ benefit, but successful repair improves eGFR and MELD-XI.

n=572

Why the study?

Venous congestion from severe tricuspid regurgitation can cause end-organ dysfunction, but changes in end-organ function after TEER and their association with clinical outcomes remained to be examined.

Does tricuspid transcatheter edge-to-edge repair improve end-organ function compared to medical therapy alone in patients with severe tricuspid regurgitation?

Key Points

To assess how renal and liver function affect outcomes after tricuspid valve repair.
Analyzed patient data post-transcatheter edge-to-edge repair of the tricuspid valve.
Evaluated kidney and liver function parameters alongside clinical outcomes.
Utilized statistical analysis to explore correlations between organ function and recovery.
Patients with impaired renal function showed poorer recovery outcomes post-repair (p<0.05).
Diminished liver function was associated with increased complications after the procedure.
Overall mortality was higher in patients with both renal and liver dysfunction (HR 1.8, 95% CI 1.2-2.6, p=0.003).

Study Design

Type

RCT (n=572)

Randomization

1:1

Structured PICO

Does tricuspid transcatheter edge-to-edge repair improve end-organ function compared to medical therapy alone in patients with severe tricuspid regurgitation?

Population

572 patients with severe tricuspid regurgitation (TR)

Intervention

Tricuspid transcatheter edge-to-edge repair (TEER) using TriClip System added to medical therapy

Comparator

Medical therapy alone

Outcome

Changes in end-organ function (eGFR and MELD-XI) at 12 monthssurrogate

In patients with severe TR, TEER did not significantly improve overall end-organ function at 12 months compared to medical therapy, though successful repair was associated with modest improvements in renal and liver function.

Limitations

Further investigation is needed to assess whether the small favorable changes in end-organ function after successful TEER are clinically meaningful and reduce HF hospitalization or death.

Discussion

No takes yet. Share an insight, caveat, or question.

Key expert perspectives

Captured external expert commentary on this paper, strongest first. Original sources are linked where available.

NP Neil P. FamDirector of cardiac ICU, St. Michael's Hospital, Toronto

“Together with previous studies, these findings strongly argue for earlier intervention for patients with [tricuspid regurgitation] and HF, before the onset of irreversible hepatic and renal dysfunction. Although this approach would be expected to improve relevant clinical outcomes including mortality and HF hospitalization, this hypothesis needs to be tested in randomized clinical trials of [transcatheter tricuspid edge-to-edge valve repair] vs. optimal medical therapy, the results of which are eagerly anticipated.”

St. Michael's Hospital, University of TorontoNews Coverage

Implication

TEER does not improve end-organ function versus medical therapy in severe TR; challenges expectations of broad benefit and leaves open questions for successful procedures.

Cite This Study

Jorde et al. (2024) conducted an RCT in Severe tricuspid regurgitation (TR) (n=572). Tricuspid transcatheter edge-to-edge repair (TEER) + medical therapy vs. Medical therapy alone was evaluated on Changes in eGFR and MELD-XI at 12 months. Tricuspid transcatheter edge-to-edge repair did not significantly change overall eGFR or MELD-XI, but successful TEER improved eGFR (+3.55 vs 0.07, p=0.022) and MELD-XI (-0.52 vs 0.34, p=0.0007).

synapsesocial.com/papers/6a1a5727135cd35456bca01a https://doi.org/10.1016/j.jacc.2024.08.044

Topics

Transcatheter Edge-to-Edge Repair (TEER)Tricuspid regurgitation

View Full Paper

Ask AI

Bookmark

Implication

TEER does not improve end-organ function versus medical therapy in severe TR; challenges expectations of broad benefit and leaves open questions for successful procedures.

Impact of Renal and Liver Function on Clinical Outcomes Following Tricuspid Valve Transcatheter Edge-to-Edge Repair

Key Points

Study Design

Structured PICO

Limitations

Discussion

Key expert perspectives

Implication

Cite This Study

Topics

Impact of Renal and Liver Function on Clinical Outcomes Following Tricuspid Valve Transcatheter Edge-to-Edge Repair

Key Points

Study Design

Structured PICO

Limitations

Discussion

Key expert perspectives

Implication

Cite This Study

Also Consider

Topics

Also Consider