October 21, 2010AJP Cell PhysiologyOpen Access

P2Y1 and P2Y13 purinergic receptors mediate Ca²⁺signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells

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Population

Pulmonary artery adventitial vasa vasorum endothelial cells (VVEC)

Design

Preclinical

Authors

TLTaras LyubchenkoNational Jewish Health HWHeather WoodwardUniversity of Indianapolis KVKristopher D. VeoUniversity of Denver

Discussion

Member takes

Implication

P2Y1/P2Y13 may mediate vasa vasorum signaling; hypothesis-generating for remodeling therapies, should not yet change practice.

Structured PICO

Population

Pulmonary artery adventitial vasa vasorum endothelial cells (VVEC)

Intervention

Extracellular nucleotides (including ATP, ADP) and purinergic receptor antagonists (MRS2179, MRS2211)

Outcome

Intracellular Ca2+ concentration ([Ca2+]i) elevation and activation of ERK1/2, Akt, and S6 ribosomal proteinsurrogate

P2Y1 and P2Y13 receptors mediate extracellular nucleotide-induced Ca2+ signaling and mitogenic responses in pulmonary artery vasa vasorum endothelial cells, suggesting they may be targets for treating pathological vascular remodeling.

Cite This Study

Lyubchenko et al. (2010) studied this question.

synapsesocial.com/papers/6a1a74b4837f1a2c63b8a135 https://doi.org/10.1152/ajpcell.00237.2010

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P2Y1 and P2Y13 purinergic receptors mediate Ca²⁺signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

P2Y1 and P2Y13 purinergic receptors mediate Ca²⁺signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider