What question did this study set out to answer?

To evaluate the efficacy and safety of low-molecular-weight heparin compared with low-dose unfractionated heparin for the prevention of venous thromboembolism in major trauma patients.

September 5, 1996New England Journal of MedicineOpen Access

A Comparison of Low-Dose Heparin with Low-Molecular-Weight Heparin as Prophylaxis against Venous Thromboembolism after Major Trauma

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Authors

WGWilliam GeertsCross-Cutting Cardiology RJRichard M. JayQueen's University Belfast KCKaren I. CodeSunnybrook Health Science Centre

Discussion

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Implication

Randomized double-blind trial demonstrates lower deep-vein thrombosis rates with enoxaparin versus low-dose heparin in major trauma, indicating superior thromboprophylaxis.

Key Points

To evaluate the efficacy and safety of low-molecular-weight heparin compared with low-dose unfractionated heparin for the prevention of venous thromboembolism in major trauma patients.
Double-blind randomized clinical trial of 344 consecutive adult trauma patients with Injury Severity Scores ≥9 and no intracranial bleeding.
Patients received subcutaneous enoxaparin (30 mg) or low-dose heparin (5000 units) every 12 hours starting within 36 hours of injury, with contrast venography performed on or before day 14.
Deep-vein thrombosis occurred in 31% (40/129) of enoxaparin patients compared to 44% (60/136) of heparin patients (P=0.014), reflecting a 30% risk reduction (95% CI, 4% to 50%).
Proximal-vein thrombosis developed in 6% (8/129) of enoxaparin recipients versus 15% (20/136) of heparin recipients (P=0.012), representing a 58% risk reduction (95% CI, 12% to 87%).
Major bleeding occurred in 1.7% of all patients (5 in the enoxaparin group versus 1 in the heparin group; P=0.12).

Cite This Study

Geerts et al. (1996) studied this question.

synapsesocial.com/papers/6a1a79457ff99bba0645ba4d https://doi.org/10.1056/nejm199609053351003

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Implication

Randomized double-blind trial demonstrates lower deep-vein thrombosis rates with enoxaparin versus low-dose heparin in major trauma, indicating superior thromboprophylaxis.

A Comparison of Low-Dose Heparin with Low-Molecular-Weight Heparin as Prophylaxis against Venous Thromboembolism after Major Trauma

Discussion

Member takes

Implication

Key Points

Cite This Study

A Comparison of Low-Dose Heparin with Low-Molecular-Weight Heparin as Prophylaxis against Venous Thromboembolism after Major Trauma

Discussion

Member takes

Implication

Key Points

Cite This Study

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