Evaluation of contractile state by maximal ventricular power divided by the square of end-diastolic volume.
Why the study?
Does maximal ventricular power divided by the square of end-diastolic volume (PWRmax/EDV2) provide a load-independent measure of ventricular contractile state?
Population
Seven open-chest, autonomically blocked dogs
Comparison
Alteration of preload, afterload, and inotropic… vs Baseline and varying loading/inotropic conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Promising preclinical index; leaves open noninvasive clinical translation pending human validation.
Structured PICO
Does maximal ventricular power divided by the square of end-diastolic volume (PWRmax/EDV2) provide a load-independent measure of ventricular contractile state?
P
Population
Seven open-chest, autonomically blocked dogs
I
Intervention
Alteration of preload (left atrial hemorrhage), afterload (intra-aortic balloon inflation), and inotropic state (lidocaine, dobutamine, propranolol, or verapamil)
C
Comparator
Baseline and varying loading/inotropic conditions
O
Outcome
Sensitivity of maximal ventricular power (PWRmax) and PWRmax/EDV2 to preload, afterload resistance, and inotropic statesurrogate
PWRmax/EDV2 provides a load-independent measure of ventricular contractile function that correlates well with established indices and has potential for noninvasive clinical application.
Cite This Study
Kass et al. (1991) studied this question.