Why the study?
Is orthostatic intolerance following 14 days of head-down tilt bed rest related to inadequate sympathetic outflow or excessive reductions in cardiac output?
Population
15 individuals who successfully completed a pre-HDBR head-up tilt test without evidence of orthostatic…
Comparison
14 days of head-down tilt bed rest (HDBR) vs Pre-HDBR baseline
Design
Cohort
Follow-up
14 days
Authors
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May implicate inadequate sympathetic compensation in post-bed rest intolerance; leaves open causal role and extension to clinical deconditioning.
Is orthostatic intolerance following 14 days of head-down tilt bed rest related to inadequate sympathetic outflow or excessive reductions in cardiac output?
Bed rest-induced orthostatic intolerance appears to be related to an inadequate increase in sympathetic discharge that cannot compensate for a greater postural reduction in stroke volume.
Shoemaker et al. (1999) studied this question.
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