Why the study?
Does 14 days of -6 degrees head-down-tilt bed rest alter sympathetic discharge and cardiovascular hemodynamics?
Population
25 subjects (n=25 for heart rate/MAP, n=16 for MSNA, n=14 for forearm blood flow, n=7 for stroke distance)
Comparison
-6 degrees head-down-tilt bed rest for 14 days vs Pre-HDBR baseline
Design
Other
Follow-up
14 days
Authors
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Alerts clinicians to monitor HR during prolonged immobilization; leaves open mechanisms of sympathetic withdrawal in deconditioning.
Does 14 days of -6 degrees head-down-tilt bed rest alter sympathetic discharge and cardiovascular hemodynamics?
14 days of head-down-tilt bed rest reduces muscle sympathetic nerve activity and stroke volume index, but increases heart rate without altering vascular resistance.
Shoemaker et al. (1998) studied this question.
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